Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
Identifieur interne : 001687 ( Main/Exploration ); précédent : 001686; suivant : 001688Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
Auteurs : Masaji Okada [Japon] ; Yoshinobu Okuno [Japon] ; Satomi Hashimoto [Japon] ; Yoko Kita [Japon] ; Noriko Kanamaru [Japon] ; Yasuko Nishida [Japon] ; Yoshie Tsunai [Japon] ; Ruriko Inoue [Japon] ; Hitoshi Nakatani [Japon] ; Reiko Fukamizu [Japon] ; Yumi Namie [Japon] ; Junko Yamada [Japon] ; Kyoko Takao [Japon] ; Ritsuko Asai [Japon] ; Ryoko Asaki [Japon] ; Tetsuo Kase [Japon] ; Yuji Takemoto [Japon] ; Shigeto Yoshida [Japon] ; J. S. M. Peiris [Hong Kong] ; Pei-Jer Chen [Taïwan] ; Naoki Yamamoto [Japon] ; Tatsuji Nomura [Japon] ; Isao Ishida [Japon] ; Shigeru Morikawa [Japon] ; Masato Tashiro [Japon] ; Mitsunori Sakatani [Japon]Source :
- Vaccine [ 0264-410X ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Immunisation passive (), Immunothérapie, Lymphocytes T cytotoxiques (immunologie), Modèles animaux de maladie humaine, Souris, Souris SCID, Syndrome respiratoire aigu sévère (), Vaccins antiviraux (administration et posologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (génétique), Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (métabolisme).
- MESH :
- administration et posologie : Vaccins antiviraux, Vaccins à ADN.
- génétique : Vaccins à ADN, Virus du SRAS.
- immunologie : Lymphocytes T cytotoxiques, Virus du SRAS.
- métabolisme : Virus du SRAS.
- Pascal (Inist)
- Animaux, Immunisation passive, Immunothérapie, Modèles animaux de maladie humaine, Souris, Souris SCID, Syndrome respiratoire aigu sévère, Virus syndrome respiratoire aigu sévère, Homme, Vaccin génétique, Immunothérapie, Grave, Modèle animal, Anticorps neutralisant, Immunodéficit mixte, Syndrome respiratoire aigu sévère, Mutation severe combined immunodeficiency (scid).
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Animal model, Animals, Combined immune deficiency, Disease Models, Animal, Genetic vaccine, Human, Immunization, Passive (methods), Immunotherapy, Mice, Mice, SCID, Neutralizing antibody, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (metabolism), Severe, Severe Acute Respiratory Syndrome (prevention & control), Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, T-Lymphocytes, Cytotoxic (immunology), Vaccines, DNA (administration & dosage), Vaccines, DNA (genetics), Viral Vaccines (administration & dosage).
- MESH :
- chemical , administration & dosage : Vaccines, DNA, Viral Vaccines.
- genetics : SARS Virus, Vaccines, DNA.
- immunology : SARS Virus, T-Lymphocytes, Cytotoxic.
- metabolism : SARS Virus.
- methods : Immunization, Passive.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Immunotherapy, Mice, Mice, SCID.
Abstract
We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000036
- to stream PascalFrancis, to step Curation: 000023
- to stream PascalFrancis, to step Checkpoint: 000035
- to stream Main, to step Merge: 001693
- to stream PubMed, to step Corpus: 000D48
- to stream PubMed, to step Curation: 000D48
- to stream PubMed, to step Checkpoint: 000D28
- to stream Ncbi, to step Merge: 000106
- to stream Ncbi, to step Curation: 000106
- to stream Ncbi, to step Checkpoint: 000106
- to stream Main, to step Merge: 001649
- to stream Main, to step Curation: 001687
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1><s2>Minamikawachi-machi, Tochigi 329-0498</s2><s3>JPN</s3><sZ>18 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Minamikawachi-machi, Tochigi 329-0498</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1><s3>HKG</s3><sZ>19 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong, Prokfulam Road</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1><s2>Jhongjheng District 100, Taipei</s2><s3>TWN</s3><sZ>20 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Jhongjheng District 100, Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjyuku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>21 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1><s2>Kawasaki, Kanagawa 216-0001</s2><s3>JPN</s3><sZ>22 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Kawasaki, Kanagawa 216-0001</wicri:noRegion></affiliation></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1><s2>Takasaki, Gunma 370-1295</s2><s3>JPN</s3><sZ>23 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Takasaki, Gunma 370-1295</wicri:noRegion></affiliation></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0226642</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0226642 INIST</idno><idno type="RBID">Pascal:07-0226642</idno><idno type="wicri:Area/PascalFrancis/Corpus">000036</idno><idno type="wicri:Area/PascalFrancis/Curation">000023</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000035</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000035</idno><idno type="wicri:doubleKey">0264-410X:2007:Okada M:development:of:vaccines</idno><idno type="wicri:Area/Main/Merge">001693</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17289225</idno><idno type="wicri:Area/PubMed/Corpus">000D48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D48</idno><idno type="wicri:Area/PubMed/Curation">000D48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D48</idno><idno type="wicri:Area/PubMed/Checkpoint">000D28</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D28</idno><idno type="wicri:Area/Ncbi/Merge">000106</idno><idno type="wicri:Area/Ncbi/Curation">000106</idno><idno type="wicri:Area/Ncbi/Checkpoint">000106</idno><idno type="wicri:doubleKey">0264-410X:2007:Okada M:development:of:vaccines</idno><idno type="wicri:Area/Main/Merge">001649</idno><idno type="wicri:Area/Main/Curation">001687</idno><idno type="wicri:Area/Main/Exploration">001687</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1><s2>Minamikawachi-machi, Tochigi 329-0498</s2><s3>JPN</s3><sZ>18 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Minamikawachi-machi, Tochigi 329-0498</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1><s3>HKG</s3><sZ>19 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong, Prokfulam Road</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1><s2>Jhongjheng District 100, Taipei</s2><s3>TWN</s3><sZ>20 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Jhongjheng District 100, Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjyuku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>21 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1><s2>Kawasaki, Kanagawa 216-0001</s2><s3>JPN</s3><sZ>22 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Kawasaki, Kanagawa 216-0001</wicri:noRegion></affiliation></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1><s2>Takasaki, Gunma 370-1295</s2><s3>JPN</s3><sZ>23 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Takasaki, Gunma 370-1295</wicri:noRegion></affiliation></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Animals</term><term>Combined immune deficiency</term><term>Disease Models, Animal</term><term>Genetic vaccine</term><term>Human</term><term>Immunization, Passive (methods)</term><term>Immunotherapy</term><term>Mice</term><term>Mice, SCID</term><term>Neutralizing antibody</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (metabolism)</term><term>Severe</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe acute respiratory syndrome</term><term>Severe acute respiratory syndrome virus</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Vaccines, DNA (administration & dosage)</term><term>Vaccines, DNA (genetics)</term><term>Viral Vaccines (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Immunisation passive ()</term><term>Immunothérapie</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris SCID</term><term>Syndrome respiratoire aigu sévère ()</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins à ADN (administration et posologie)</term><term>Vaccins à ADN (génétique)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, DNA</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term><term>Vaccines, DNA</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vaccins à ADN</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T cytotoxiques</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Immunotherapy</term><term>Mice</term><term>Mice, SCID</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Immunisation passive</term><term>Immunothérapie</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris SCID</term><term>Syndrome respiratoire aigu sévère</term><term>Virus syndrome respiratoire aigu sévère</term><term>Homme</term><term>Vaccin génétique</term><term>Immunothérapie</term><term>Grave</term><term>Modèle animal</term><term>Anticorps neutralisant</term><term>Immunodéficit mixte</term><term>Syndrome respiratoire aigu sévère</term><term>Mutation severe combined immunodeficiency (scid)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>Japon</li><li>Taïwan</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name></noRegion><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name></country><country name="Hong Kong"><noRegion><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name></noRegion></country><country name="Taïwan"><noRegion><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001687 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001687 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:07-0226642
|texte= Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
}}
| This area was generated with Dilib version V0.6.33. |  |